ProSep is a novel gas chromatography separation method that eliminates solvent before the column by installing a pre-separation column at the injection point, thereby avoiding the interference of solvent and improving the sensitivity. It shows excellent performance in a wide range of applications.
The APEX ProSep 800 XT Plus Precolumn Separation Inlet functions as an independent chromatographic zone to selectively reduce or eliminate injected components before they enter the analytical column. This technology allows for the removal of solvents and high-boiling matrix contaminants, thereby improving analytical integrity and reducing maintenance requirements for sensitive detectors like mass spectrometers.
The document presents experimental results using a four-component mixture injected via large-volume injection (LVI). It demonstrates the system's ability to selectively attenuate early-eluting impurities like dodecane and late-eluting matrix interferences like methyl palmitate without affecting the analytes of interest.
The system allows for injection volumes up to 125-u1.
The precolumn that fits inside the module is 24 cm in length.
The system can reduce the amount of such a component by approximately 50-fold.