Cap analog AU Sodium Solution 100mM is designed for mRNA co-transcriptional 5'-capping, producing mRNA with natural Cap 1 structure. Cap Analog AU is designed for self-replicating RNA based on the genome of positive-strand RNA viruses, such as Venezuelan Equine Encephalitis Virus (VEEV), Semliki Forest Virus (SFV) and Sindbis Virus (SIN). The positive-strand genomes of these viruses begin with 5'-AU, and Cap 1 mRNA has superior in vivo activity compared to Cap 0 mRNA produced by the traditional co-transcriptional 5'-capping method Anti-reverse cap analog (ARCA) can be used with modified NTPs.
