An adaptive programmable operation method of power grid regulation, including receiving camera data collected as operating objects in the substation management substation, converting the camera data into 0 and 1 position signals, and the main station of substation management through the web page of dispatching automation system main station through the reverse isolation device The position signal is inversely transmitted to the dispatching automation system main station. The programmed control module sends the operation instruction through the web page of the dispatching automation system main station to the substation operation management platform. The substation controls the operation object according to the operation instruction. The position signal of the operation object is sent to the web page of the dispatch automation system main station. During the operation, the operating personnel judge whether the operating object meets the requirements based on the monitoring screen of the dispatching automation management platform. The double confirmation of the operation equipment position and operating status improves the reliability of the adaptive programmable operation of the power grid regulation.