Bond Elut Plexa is a new generation of polymer-based SPE products, featuring a new hydroxylated outer layer and advanced polymer architecture. It simplifies and improves analytical performance, offering easy extraction methods, excellent flow characteristics, and convincing analytical performance for fast and hassle-free validation. The simple extraction with Bond Elut Plexa yields pure extracts and improves recovery of a variety of acidic, basic, and neutral analytes. Its advanced polymer design effectively eliminates matrix effects that would otherwise cause ion suppression, resulting in excellent analytical sensitivity and data quality.