Agilent Effect of Silica-Support Type - Reversed-Phase Separation of Tricyclic Antidepressants

Update: 30 September, 2023

This document describes the use of highly purified, less-acidic Type-B silica support (ZORBAX Rx-SIL) in reversed-phase separation of tricyclic antidepressants, which resulted in improved band shape and column efficiency for these basic drugs. Reduced retention for column with Type-B silica is due to lower surface area of its support.


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MD5 Checksum: D71C746F398C0FF7B8942980D40B9200

Publication date: 03 July, 2012

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