Update: 29 September, 2023
This article introduces the improved response for active compounds using the Direct Connect Liners technique. The Direct Connect Liners is a commonly used inlet for trace compound analysis and splitless injection technique. This technique is rugged, robust, and sensitive as a large portion of the sample is delivered to the column. The key to the technique is vaporization in the inlet, facilitated by the inlet liner. Liners are typically made of straight, deactivated borosilicate glass with a tapered bottom to prevent contact with the metal baseplate of the inlet. Liners with tapers at the bottom and the top are also popular as they provide better containment of the injected sample. This is important for difficult or active compounds that tend to be lost or irreversibly adsorbed in the inlet. These compounds are often highly polar and are typically acidic or basic compounds. In theory, the response factor should be constant and independent of the amount injected. Typically, the response factor (detector signal per weight of compound injected) is smaller at lower concentrations than at higher concentrations. The lowered response is more apparent at small concentrations.
File format: PDF
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MD5 Checksum: 82EFBD42959D7A98EB20475D1E311B30
Publication date: 05 July, 2012
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PDF Link: Agilent Direct Connect Liners: Improved Response for Active Compounds Manual PDF