Update: 29 September, 2023
This Technical Note compares the Agilent 1100 Series diode array detector (DAD) “B” model to its successor the Agilent 1200 Series DAD “D model”. For this comparison both detectors were interchangeably connected to an Agilent 1100 Series LC system. To exclude undesired instrument bias the same Agilent 1100 Series LC system was used for both series of experiments. The evaluated performance criteria included retention time, peak width, resolution, peak area, peak height, signal-to-noise, limit of detection, limit of quantitation and linearity. Overall, the Agilent 1200 Series DAD compared favorably to the Agilent 1100 Series DAD, delivering the same or even noticeably better results. Based on these results it was concluded that an Agilent ChemStation method that was developed and validated on an 1100 Series DAD is fully compatible with the 1200 Series DAD. This means that an 1100 Series DAD can be replaced by a 1200 Series DAD with no or minimal revalidation effort.
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MD5 Checksum: 6E300FD94C92E850CF89E366BAB04697
Publication date: 05 July, 2012
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PDF Link: Agilent Seamless transfer of Methods to the New Agilent 1200 Series Diode Array Detector Manual PDF