Update: 28 September, 2023
The document describes the features and characteristics of the Agilent 971-FP Flash Purification System and its application in discovery applications. The system allows purification of complex samples by running the longest Agilent SuperFlash column at a flow rate of 40 mL/min without exceeding the maximum operating pressure. Agilent offers a complete flash purification solution including the 971-FP instrument, IntelliFlash software, and SuperFlash columns for drug discovery applications. These applications typically require purification of milligram to several gram quantities of a synthetic compound from a synthesis mix. To achieve high efficiency for related compounds, smaller particle media and longer column lengths are used. The SuperFlash SF25-160 g Si 35 column is a normal phase column packed with high efficiency 35 µm silica. It has an aspect ratio of 16.2:1 and is designed for purifying complex mixes in the range of 1.6 g to 16 g. Investigations of the operating pressure of this column determined the maximum pressure reached during purification using the IntelliFlash software at the default flow rate for this column id and a gradient from 0 to 100% ethyl acetate.
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MD5 Checksum: 0816E04384F69AA8A5DEC12735C8923D
Publication date: 05 July, 2012
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PDF Link: Agilent Is pressure really a problem for the Agilent 971-FP Flash Purification System Manual PDF