Update: 30 September, 2023
This document describes a new HPLC method for the determination of the tricyclic antidepressant doxepin in 'Aponal 100' tablets. The method uses an extra densely bonded Eclipse XDB-C18 column, which is made with a special Zorbax silica support and designed to reduce or eliminate strong adsorption of basic or acidic compounds. The method is stable at neutral pH and shows excellent and rapid resolution of tricyclic aromatic amines at low buffer concentration. Doxepin is separated from 'Aponal 100' tablets with no interference from excipients.
File format: PDF
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MD5 Checksum: D8AF9A2942EA3CBDFF2B465E8F4256A6
Publication date: 03 July, 2012
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PDF Link: Agilent Technologies Tricyclic Antidepressant: HPLC Analysis of Doxepin in \ PDF