Update: 30 September, 2023
This paper presents seven examples of pharmaceutical analyses employing ZORBAX Eclipse Plus C8 columns. Eclipse Plus C8 is an excellent starting point for method development because of its excellent peak shape for bases, acids, and neutrals. Excellent peak shape contributes to better peak resolution. Eclipse Plus C8 exhibits different selec- tivity compared to Eclipse XDB C8 and Eclipse Plus C18. The shorter aliphatic C8 chain is less retentive than a C18 chain and can significantly cut analysis time compared to C18. Additionally, there is a wide variety of column con- figurations available for all analytical, rapid-resolution (RR), and high-throughput analyses. Several of these examples are scaled down from analytical methods to RR methods by substituting the longer column with a RR column. This combination of excellent peak shape and scalability to high-throughput methods make Eclipse Plus C8 a valuable tool to increase productivity wherever HPLC is used.
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Publication date: 02 July, 2012
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