Update: 30 September, 2023
A fast, sensitive, and validated technique for confirming the presence of amphetamine drugs in whole blood using the Agilent G6410A Triple Quadrupole Mass Spec-trometer (QQQ) is presented. Excellent linearity is demon- strated over the range of approximately 15 to 1,000 ng/mL. The amphetamine drugs analyzed in this work include amphetamine, methamphetamine, methyl-enedioxyamphetamine (MDA), and methylenedioxymeth-amphetamine (MDMA) in blood. The drugs have been prepared using an extractive alkylation technique. The sample preparation is then followed by reverse-phase LC/MS/MS using a 1.8-µm particle size C18 column for high chromatographic resolution with a high-speed sepa-ration. As a result, elution times for both analytes and internal standards are all less than or equal to 3.6 min- utes.
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MD5 Checksum: 1A54E9508AB8BF448F258D97796DDE42
Publication date: 02 July, 2012
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