Agilent Technologies Analysis of metabolites from beta blocking drugs in biological samples using an Agilent 1100 Series capillary LC/Trap XCT system

Update: 30 September, 2023

This Application Note describes how a S9 human liver homogenate was used to simulate oxidative phase 1 metabolism of the beta-blocking drugs propranolol, metoprolol and pindolol. Afterwards, the samples were partially purified by precipitation/extraction with trifluoroacetic acid and hexane, followed by analysis with an Agilent 1100 Series LC/MSD trap XCT system. Fully automated LC/MS and LC/MSn analysis allowed for identification of the metabolites produced by the liver homogenate.

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Publication date: 02 July, 2012

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