Agilent Technologies Impact of Ion-Pair Reagents on LC/MS Analysis

Update: 30 September, 2023

The effects of four different ion-pair reagents (weak and strong volatile ion-pair reagents and nonvolatile strong ion-pair reagents) in positive and negative ionization modes are compared. The results show that the strength and volatility of the ion-pair reagent have a great influence on the formation of the ion pair and the resulting ion-pair effect. Strong volatile ion-pair reagents show good performance in both positive and negative ionization modes, while nonvolatile strong ion-pair reagents show good performance in positive ionization mode.


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Publication date: 02 July, 2012

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