Agilent Improving productivity in the determination of parameters for early in vitro ADME - Part 4 Experimental details results of plasma protein binding assay

Update: 30 September, 2023

This Application Note describes the experimental details and results of a plasma protein binding (PPB) assay. The approach and methodology of rapid resolution liquid chromatography and triple quadrupole mass spectrometry used in this study are described in a separate Application Note1. Experimental details and results of other typical assays per- formed in early ADME profiling of new hits are presented in separate publications2,3.

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Publication date: 02 July, 2012

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