Agilent Ultra-high throughput determination of CYP450 enzyme inhibition through mass spectrometry

Update: 30 September, 2023

This Application Note describes how the BioTrove RapidFire high-throughout mass spectrometry (RF-MS) system interfaced to an Agilent 6410 triple quadrupole mass spectrometer was used for the characterization of the enzymatic reaction of CYP450 3A4/5 enzyme in a preparation of human liver microsomes and for the determination of IC50 curves of poten- tially inhibiting drug compounds.

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Publication date: 02 July, 2012

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