Update: 30 September, 2023
This Application Note describes a rapid and sensitive method for quantification of fluvastatin in plasma using the Agilent 1200 Series Rapid Resolution Liquid Chromatography (RRLC) system and the Agilent 6410 Triple Quadrupole LC/MS system. Sample preparation was carried out by a simple protein precipitation step. Atorvastatin at 40 ng/mL was used as the internal standard. The developed method had a short run time of two minutes and was found to be linear in the concentration range of 0.5 ng/mL to 200 ng/mL. The limit of detection (LOD) of the method is 0.2 ng/mL, or 1 pg on-column.
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Publication date: 02 July, 2012
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