Update: 28 September, 2023
This article describes the quantification of potential genotoxic impurity D in Atenolol using LC/ESI/MS/MS method with Agilent 1200 Series RRLC and 6410B Triple Quadrupole LC/MS instruments. The developed method is simple, shorter in runtime, with better resolution and higher sensitivity than the existing European and United States Pharmacopeia methods. Agilent's MassHunter Optimization software was used for quick optimization of MS parameters. By connecting the Agilent 6410B Triple Quadrupole (QQQ) LC/MS detector to an Agilent 1200 Series RRLC system, the quantification range can be effectively reduced further down to 5 ppb with a linearity coefficient greater than 0.9992.
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Publication date: 02 July, 2012
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