Update: 30 September, 2023
This Application Note demonstrates the use of rapid resolution liquid chromatography in conjunction with tandem mass spectrometry to study the plasma stability of phar- maceutical compounds belonging to four different drug classes. The Agilent 1200 Series Rapid Resolution LC system (RRLC) provided fast separation of compounds and internal standard in all samples. The Agilent MassHunter Optimizer software identi- fied compound-specific MS parameters such as the most abundant product ions, opti- mal fragmentor voltages and collision energies. Taken together, robust methods for a larger set of compounds could be developed within a short period of time.
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MD5 Checksum: 33AE2AD4983995E08B75C551980E89D7
Publication date: 02 July, 2012
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