Update: 30 September, 2023
The Dynamic MRM (DMRM) algorithm in the Agilent 6400 Series Triple Quadrupole LC/MS system automatically constructs DMRM timetables for multiple analytes throughout the LC/MS analysis based on the retention time window for each analyte. It allows the instrument to acquire MRM data only during a stated retention time window, thus reducing the number of concurrent ion transitions. In this study, 194 MRM transitions from a digest of complex protein standard was analyzed using DMRM and MRM modes in the Agilent 6410 Triple Quadrupole LC/MS system. Improved sensitivity, better peak symmetry, and up to ten-fold increase in the signal-to-noise (S/N) ratio are achieved using DMRM.
File format: PDF
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MD5 Checksum: 1B857362D99D4F61AA9AA907E5312A21
Publication date: 02 July, 2012
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PDF Link: AGILENT Dynamic MRM: A Clear Advantage for High-throughput Protein Quantitation Application Note PDF