Update: 29 September, 2023
This document describes the method for the detection of β-lactam antibiotics in milk. These antibiotics are widely used in veterinary medicine for the treatment and prevention of diseases. The presence of residues in milk and edible tissues can cause problems in fermentation processes and health issues for individuals hypersensitive to β-lactams. To protect consumers, maximum residue limits (MRL) were set in EU regulation 2377/90. For milk, these values range from 4 µg/kg for penicillin G, ampicillin, and amoxicillin to 30 µg/kg for dicloxacillin, cloxacillin, and oxacillin. Screening is usually performed using microbiological and immunological methods. Confirmation, however, requires an independent physicochemical technique. Therefore, a highly sensitive LC/MS/MS method was developed for the detection of penicillins in milk samples.
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Publication date: 12 June, 2012
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