Update: 30 September, 2023
This application note outlines a viable method for reliably detecting low-fem- togram levels of perfluorinated carboxylates (PFCA) and sulphonates (PFSA) without background component interference, with an inline contaminant trap LC modification. Good chromatographic resolution of all perfluorinated compounds was observed. A representative suite of PFCAs and PFSAs were analyzed herein and were all detected at on-column levels lower than 75 fg in drinking water matrices (S/N >3.) The most sensitive analytes PFHxS, PFDS and PFBS were detected at 2.6, 3.2 and 5 fg levels, respectively. Method detection limits for spiked pork liver matrix extract samples were below 600 fg on-column for the entire analyte suite. No detectable background conta- mination was observed in blank injections for any analyte in this study. Linearity for up to five orders of magnitude with R2 values above 0.996 for the entire suite were recorded.
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MD5 Checksum: FA5F7111F47388D0EF3EFDC87574D7EC
Publication date: 12 June, 2012
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