Update: 28 September, 2023
This document describes the quantitation of a dinitro flavonoid (DNF) in rat plasma using the Varian 1200L LC/MS/MS system. Flavonoids are compounds that make up the pigments in fruits, vegetables, and herbs. There have been reports of flavonoids having multiple beneficial therapeutic effects for a large number of serious illnesses, such as rheumatoid arthritis, cancer, cataracts, anxiety, and depression. The objective of this work was to carry out a pharmacokinetic evaluation to determine a profile with the formulation being tested at increasing doses where there is pharmacological effect. A Varian 1200L LC/MS/MS system was used for the quantitation of plasma levels of a novel dinitro-substituted flavone (DNF) in samples from a pharmacokinetic study following oral administration of the drug. Flavone was used as the internal standard. Structures are shown in Figure 1.
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Publication date: 12 June, 2012
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