Update: 30 September, 2023
This application note presents a method for the analysis of adulterants in weight loss supplements marketed as “all natural.” The analysis is performed using the Agilent 500 Ion Trap LC/MS with Turbo Data Dependent Scanning (TurboDDS), which performs full scan and MS/MS analysis in a single injection. Target adulter- ants were observed and yielded spectra with excellent library matches to the NIST MS Library when spiked into a dietary supplement matrix at 10 µg/mL and then diluted 1:10 in water. A real incurred weight loss product was also analyzed and found to be adulterated with Bumetanide. Unlike other techniques that use targeted analysis to detect known adulterants in a dietary supplement of interest, TurboDDS screens and identifi es both known and unanticipated adulterants in a single experiment.
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MD5 Checksum: 212EB1EC2A03F329B44A1375895BBB45
Publication date: 11 June, 2012
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