Update: 30 September, 2023
This document describes the use of the Agilent 1260 Bio-inert Quaternary LC system for sensitive and rapid LC methods to characterize the therapeutic protein, P128. Optimized peptide maps were constructed using sub-2-µm column technology to decrease analysis speed for this protein. Size exclusion chromatography (SEC) and ion exchange chromatography (IEX) were performed using the new Agilent Bio-HPLC columns to detect potential impurities or isoforms of the protein preparation. The bio-inertness and corrosion resistance of the instrument coupled with the simple and reproducible methods make this solution suitable for routine use in QA/QC labs.
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Publication date: 11 June, 2012
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