Update: 29 September, 2023
Due to the current global acetonitrile shortage, Agilent Technologies has been investigating a range of alternative solvents that could be used for reversed phase HPLC analysis of peptides, which maintain the efficiency and selectivity that a PLRP-S 100Å 10 µm gives for this application when used with acetonitrile. This report details how a 385-LC ELS detector can be used to prevent the increased background absorbance of the mobile phase eluents when run on a UV detector. The 385-LC ELSD is capable of evaporating a wide range of different solvents, resulting in completely flat baselines and sharp peaks, even during gradient elution.
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MD5 Checksum: 6F27CCD28A36CE82AAD2F882B5F19BAC
Publication date: 11 June, 2012
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