Agilent Chiral impurity analysis enantiomeric excess determination with the Agilent 1260 Analytical SFC system handbook

Update: 30 September, 2023

This file describes the chiral separation and enantiomeric excess (EE) determination of three model chiral compounds using Supercritical Fluid Chromatography using the Agilent 1260 Infinity Analytical SFC system. The low detector noise of the system due to the SFC pump technology resulted in excellent sensitivity for trace analyte detec- tion of chiral impurities. When applying method optimization sufficient resolution was achieved for all compounds even under mass overload conditions. This allowed for the quantitation of impurities at 0.05 to 0.1% levels.

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Publication date: 11 June, 2012

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