Update: 29 September, 2023
This document presents a method for SAMHSA-compliant LC/MS/MS analysis using Agilent Bond Elut Plexa PCX and Agilent Poroshell 120. The method meets SAMHSA guidelines and provides measurement of linearity, limit of detection (LOD), accuracy and precision, matrix effects, extraction recovery, and overall process efficiency. The method utilizes premier Agilent products including Agilent Bond Elut Plexa PCX mixed-mode polymeric SPE sorbent, Agilent Poroshell 120 EC-C18 2.7 µm superficially porous LC column, Agilent 1200 Infinity LC system, and Agilent 6460 Triple Quadrupole LC/MS system.
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Publication date: 11 June, 2012
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