Update: 28 September, 2023
This application note describes the combination of mass spectrometry and evaporative light scattering detection as a powerful tool for the analysis of pharmaceuticals. An Agilent 500 Ion Trap MS was coupled to an Agilent 385-ELSD Evaporative Light Scattering Detector for quantification of Haloperidol and its metabolites, Diazepam and Verapamil, and Ibuprofen and ß-cyclodextrin. Mass spectrometry is highly sensitive and widely used as an information rich detector, but it is not universal and some analytes do not ionize well using standard ion sources. This problem can be overcome by coupling to another kind of detector such as an evaporative light scattering detector, which has many advantages over refractive index and ultraviolet detectors.
File format: PDF
Size: -
MD5 Checksum: 109B44FC5A1F299E5988B31857EEE393
Publication date: 11 June, 2012
Downloads: -