Update: 30 September, 2023
This application describes the development of a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of estrone-3-sulfate (E1S) in water with a sensitivity below the ppt level (< ng L-1). The method involves solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC-MS/MS) in negative electrospray mode. The method achieved high recoveries (>93%) and low detection limits (<1 pg L-1). In addition, the method was highly selective, with no interferences from other compounds observed. This makes it a suitable method for the analysis of E1S in environmental water samples.
File format: PDF
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MD5 Checksum: 49515B975AB45479E2CE0B5A2E3598EB
Publication date: 08 June, 2012
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PDF Link: Agilent Determination of Estrone-3-Sulfate in Water at Sub-ppt Level by LC-(ESI-)- MS/MS Manual PDF