This guide provides an overview of supporting employment (SE) in patients with spinal cord injury (SCI). The guide focuses on the predictive employment model from the PrOMOTE project, which was developed to help SE providers determine the level of support that SCI patients need to transition from training to employment. The guide also provides information on key issues and challenges in SE implementation, including how to work with SCI patients, spouses, families, employers, and other stakeholders.