The document introduces the features and performance of the Precision Picoampere Input Current Quad Operational Amplifier OP497 Rev. E. The features include low offset voltage, low offset voltage drift, very low bias current, very high open-loop gain, low supply current, and high common-mode rejection. It is suitable for applications such as strain gage and bridge amplifiers, high stability thermocouple amplifiers, instrumentation amplifiers, photocurrent monitors, high gain linearity amplifiers, long-term integrators/filters, sample-and-hold amplifiers, peak detectors, logarithmic amplifiers, and battery-powered systems.