Agilent Technologies Reduction of Ionization Suppression in Water Samples when Using LC-ESI-MS in Negative Ion Mode Application Note

Update: 28 September, 2023

This document describes experimental modifications to inhibit ionization suppression when using LC-ESI-MS in negative ion mode for steroid estrogens and acidic herbicides. It introduces the problem of ionization suppression and methods to reduce its effects. The application of matrix clean-up in water samples to improve the apparent extraction efficiency of the analyte of interest when using LC-ESI-MS in negative ion mode is also discussed.

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MD5 Checksum: 14733B421069D86C4733B915879631B5

Publication date: 02 July, 2012

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