Agilent Technologies Identification of Dextromethorphan Metabolites in Urine Application Note

Update: 29 September, 2023

The document describes the metabolism of drugs in the body and the impact of enzyme activity on the formation and excretion rate of metabolites. The CYP3A4 and CYP2D6 enzyme families are considered the most important in this activity. The document uses dextromethorphan as a probe for the activity of the CYP2D6 metabolic phenotype and describes the metabolism and excretion of the drug in different metabolic types of patients. Additionally, the document mentions that some individuals have multiple copies of the gene that produces the CYP2D6 enzymes, leading to high metabolic rates of many drugs in these individuals and rendering the drugs therapeutically ineffective.

Brand: Agilent

File format: PDF

Size: 1046 KB

MD5 Checksum: 678C3BA4AF2890E40691C2574A9E61F2

Publication date: 02 July, 2012

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PDF Link: Agilent Technologies Identification of Dextromethorphan Metabolites in Urine Application Note PDF

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