Update: 30 September, 2023
This Application Brief describes the use of an Agilent 6410 Triple Quadrupole Mass Spectrometer (QQQ) to analyze perfluorooctanoic acid (PFOA). A simple isocratic elution is carried out on a Rapid Resolution High Throughput C18 column (particle size 1.8 µm) with only water and methanol solvents containing 10 mM ammonium acetate. Elution time for standard dilutions of PFOA is only 2.3 minutes. Good linearity over more than 4 orders of magnitude, from 9 fg/µL to 150 pg/µL, is demonstrated with excellent peak area reproducibility of 5.5 % RSD at the 9 fg/µL level. The average peak-to-peak signal-to-noise (S/N) ratio at this level is 7.2. Sensitivity of surface water extracts is expected to be similar.
File format: PDF
Size: -
MD5 Checksum: B840113673BB24EA350F45329F946FB8
Publication date: 02 July, 2012
Downloads: -
PDF Link: Agilent Quantitative Analysis of Perfluorooctanoic Acid by LC/MSMS PDF