The patent application relates to an intelligent mine drainage optimization control system and method for mine pump room, including a PLC controller, a ground remote centralized control center, a PC, a transmission network, a sensor set, a data acquisition system, a monitoring system, an alarm system, the said PLC controller includes a CPU, a communication template, a digital input template, a digital output template, an analog input template, a power template, a frame, the said transmission network uses industrial Ethernet or PROFINET network communication mode, the said ground remote centralized control center is equipped with a human-machine interface, the control method adopts the establishment of a central monitoring layer, PLC control layer, on-site equipment layer three-level control mode, establish uniform wear control algorithm of drainage system, peak and valley power price difference for water pump drainage optimization management method, the method can realize the automation of mine drainage system operation optimization and protection control, reduce the labor intensity of personnel, system uniform wear control algorithm can extend the service life of equipment, and thus meet the requirements of system reliability and safety.