Didanosine is an antiretroviral drug that acts by preventing multiplication of the human immunodeficiency virus (HIV). Didanosine is a nucleoside reverse transcriptase inhibitor. It acts by inhibiting the reverse transcriptase enzyme. The virus needs this enzyme to multiply in the body. Didanosine is used in combination with other antiretroviral drugs to slow progression of the disease and reduce the risk of opportunistic infections (AIDSrelated infections). Didanosine does not cure AIDS nor kill the virus. There is a permanent risk of transmitting HIV either through sexual or blood contact. It is therefore essential that precautions always be taken (latex condoms, clean syringes, etc.). Fertile women must use an effective means of birth control.