Update: 30 October, 2023
Disclosed is a compound captopril nifedipine pulse controlled release preparation and its preparation method, the formulation comprising captopril pulse controlled release microsphere and nifedipine controlled release microsphere; wherein captopril pulse controlled release microsphere realizes drug twice pulse release. The technical scheme of the invention is to adopt the principle and method of circadian pharmacology, according to the rhythmic changes of human body and the diurnal rhythm of hypertension and developed a captopril pulse controlled release microsphere and nifedipine controlled release microsphere mixed compound capsule preparation. The invention can achieve time-limited release, which can reduce the peak blood pressure to the normal range and not make the blood pressure lower than the normal range during non-peak periods, to achieve the best drug efficacy and the smallest adverse reactions. The invention is taken in the evening, and the drug is released in a pulse form in the morning when the blood pressure is highest, so that the patient's own biological rhythm and efficacy can achieve a good balance, and the number of medication can be reduced. Compared with traditional preparations, it is safer, more convenient and effective.
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MD5 Checksum: CE6584C6CA4C9F9E64C3F9CD017A74C6
Publication date: 30 October, 2023
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PDF Link: A compound captopril nifedipine pulse controlled release preparation and its preparation method PDF