Acute myocardial infarction is a clinical syndrome characterized by sudden myocardial ischemia and necrosis due to coronary artery thrombosis or occlusion, resulting in severe coronary artery stenosis. It is generally believed that ST-segment elevation myocardial infarction (STEMI) is a complete coronary artery occlusion, and active revascularization should be performed, that is, thrombolysis or direct percutaneous coronary intervention, to open the infarct-related artery. Currently, with the promotion of thrombolysis technology, the attention to thrombolysis has been reduced. Although thrombolysis has the advantages of high recanalization rate and fewer complications compared with interventional therapy, only a few urban hospitals in Hubei Province and even the whole country can perform thrombolysis. Thrombolysis has the advantages of being fast, simple and easy to operate, and is still an indispensable revascularization therapy. According to the investigation by the Hubei Provincial Chest Pain Center Alliance, up to 15% of STEMI patients did not receive interventional treatment within the prescribed time window. The area of Hubei Province's remote urban areas and mountains accounts for 20%, and the time delay caused by transfer seriously restricts the efficacy of intervention. In this case, thrombolysis is the best choice for these patients. Therefore, the Hubei Provincial Chest Pain Center Alliance, in conjunction with the Hubei Provincial Thrombosis and Hemostasis Center, has formulated this expert suggestion by referring to the latest guidelines. It promotes thrombolysis treatment for medical institutions that are not able to perform intervention under the premise of no time delay, aiming to achieve zero delay in revascularization treatment of STEMI.